Simple citrate anticoagulation protocol for low flux haemodialysis
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چکیده
منابع مشابه
Simple citrate anticoagulation protocol for low flux haemodialysis
BACKGROUND For patients unable to receive heparin anticoagulation during haemodialysis, saline flushes to reduce circuit clotting are often the norm. Regional citrate anticoagulation (RCA) although effective is not used by many centres including in Singapore. We wanted to demonstrate the superiority and safety of a simple regional citrate anticoagulation regime, compared to saline flushes, for ...
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BACKGROUND Low-molecular weight heparin (LMWH) is commonly used as an anticoagulant for haemodialysis by a single-bolus injection. However, its application in extended haemodialysis has been infrequently studied. In particular, for nocturnal home haemodialysis patients sleeping throughout treatment, the need for additional intradialytic bolus might render the use of LMWH impractical. To overcom...
متن کاملCitrate pharmacokinetics and calcium levels during high-flux dialysis with regional citrate anticoagulation
BACKGROUND Regional citrate anticoagulation is a very effective anticoagulation method for haemodialysis. However, it is not widely used, primarily due to the risk of hypocalcaemia. We studied citrate and calcium kinetics to better understand safety aspects of this anticoagulation method. METHODS During 15 haemodialysis treatments with a calcium-free dialysis solution, citrate was infused pre...
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In hemodialysis, the patient’s blood is flown through an extracorporeal circuit containing a hemodialyzer. This process stimulates coagulation for several reasons, most notably the blood’s contact with the artificial surfaces of the tubing and dialyzer membrane and with air in the venous bubble trap, turbulent and stagnant blood flow, shear stress and hemoconcentration during the treatment [1]....
متن کاملAnticoagulation during haemodialysis using a citrate-enriched dialysate: a feasibility study.
BACKGROUND The feasibility of anticoagulating the extracorporeal circuit during haemodialysis using a simple citrate-enriched dialysate was evaluated in a prospective, randomised, cross-over study of 24 patients who were at high risk for bleeding. METHODS A dialysate, with a citrate level of 3 mEq/L (1 mmol/L), was generated by adding citrate to the conventional liquid 'bicarbonate concentrat...
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ژورنال
عنوان ژورنال: BMC Nephrology
سال: 2018
ISSN: 1471-2369
DOI: 10.1186/s12882-018-0811-y